What is Zeolite

What is Zeolite

• CaAl2Si7O18
• Other cations: Na+, K+, Mg2+
• Applicable for animal and human use
• Ion-exchangers; adsorbents; animal feed additives, antacids, drugs (Enterex), anti caking agents – EC12991, No. 2200/2001; October 17, 2001

Toxin Removal

Zeosen® efficiently adsorbs and immobilizes:

• Mycotoxins (ochratoxin and aflatoxin B1)
• Nitrosamines
• Dioxines
• Heavy metals (Pb, Hg, Cd, As) and ammonia
• Bacterial toxins and viruses

1. Colloids Surf B Biointerfaces. 2005 Nov 25;46(1):20-5. Epub 2005 Sep 28. Adsorption of mycotoxins by organozeolites.Daković A, Tomasević-Canović M, Dondur V, Rottinghaus GE, Medaković V, Zarić S. Institute for Technology of Nuclear and Other Mineral Raw Materials, P.O. Box 390, 11000 Belgrade, Serbia and Montenegro.
2. Chemosphere 58 (2005) 109–114 Adsorption of nitrosamines in acidic solution by zeolites Chun Fang Zhou, Jian Hua Zhu Department of Chemistry, Nanjing University, Nanjing 210093, China
3. Journal of Colloid and Interface Science 280 (2004) 309–314. The removal of heavy metal cations by natural zeolites E. Erdem a, N. Karapinar b, R. Donat a,a Department of Chemistry, Faculty of Science and Arts, Pamukkale University, 20017 Denizli, Turkey-Department of Chemistry Engineering, Faculty of Engineering, Pamukkale University, 20017 Denizli, Turkey
4. Colloids Surf B Biointerfaces. 2008 Jun 15;64(1):88-97. Epub 2008 Jan 25. Selective adsorption of bacterial cells onto zeolites.Kubota M, Nakabayashi T, Matsumoto Y, Shiomi T, Yamada Y, Ino K, Yamanokuchi H, Matsui M, Tsunoda T, Mizukami F, Sakaguchi K.Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba-ken 278-8510, Japan.
5. Science Direct: Microporous Materials: 1387/1811 . Antiviral properties of clinoptilolite, Grce, Pavelic, Ruder Bosković Institute, Division of Molecular Medicine, Zagreb, Croatia

Immune Modulation

Zeosen® interacts in galt which induces:

• Increased macrophage and DC response
• CD4 CD8 proliferation
• Improvement of gut cellular barrier

1. J Cancer Res Clin Oncol. 2002 Jan;128(1):37-44. Epub 2001 Nov 10. Immunostimulatory effect of natural clinoptilolite as a possible mechanism of its antimetastatic ability. Pavelic K, Katic M, Sverko V, Marotti T, Bosnjak B, Balog T, Stojkovic R, Radacic M, Colic M, Poljak-Blazi M. Rudjer Boskovic Institute, Division of Molecular Medicine, Bijenicka 54, HR-10000 Zagreb, Croatia.
2. Adv Ther. 2004 Mar-Apr;21(2):135-47. Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system. Ivkovic S, Deutsch U, Silberbach A, Walraph E, Mannel M.Megamin GmbH, Berlin, Germany

Silicon Supplementation

Micronized Zeolite is highly effective source of bioavailable silicon (H₄SiO₄), therefore promoting:

• Collagen and elastin synthesis
• Faster bone growth and mineralization
• Improved tendon strength (reduction of injury)
• Faster growth and thicker and lustre hair (coat, fur)

1. J Cell Biochem. 1995 May;58(1):39-46.  Zeolite A inhibits osteoclast-mediated bone resorption in vitro. Schütze N, Oursler MJ, Nolan J, Riggs BL, Spelsberg TC. Department of Biochemistry, Mayo Clinic, Rochester, Minnesota 55905, USA.
2. Autocrine signals promote osteoblast survival in culture A Tumber, M C Meikle and P A Hill  Bone Biology Unit, Department of Orthodontics and Paediatric Dentistry, Guy’s, King’s and St Thomas’ Hospital’s Medical and Dental Schools, Guy’s Hospital, St Thomas’ Street, London SE1 9RT, UK
3. Adv Drug Deliv Rev. 2005 May 25;57(7):959-71. Epub 2005 Apr 15. Mechanism of osteoclast mediated bone resorption–rationale for the design of new therapeutics. Väänänen K. Department of Anatomy, Institute of Biomedicine, University of Turku, FI-20700 Turku, Finland.
4. Nutr Metab (Lond). 2013 Jan 8;10(1):2. doi: 10.1186/1743-7075-10-2. Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy. Jurkić LM1, Cepanec I, Pavelić SK, Pavelić K.

Antioxidant Effect

• SOD, Catalase and peroxidase enzymes are stimulated by Micronized Zeolite therefore reducing oxidation, peroxidation and lipid peroxidation.
• Micronized Zeolite adsorbs hydroxyl radical, molecule which wreaks havoc in body

1. Anticancer Res. 2003 Mar-Apr;23(2B):1589-95. Anticancer and antioxidative effects of micronized zeolite clinoptilolite. Zarkovic N, Zarkovic K, Kralj M, Borovic S, Sabolovic S, Blazi MP, Cipak A, Pavelic K.Ruder Boskovic Institute, Division of Molecular Medicine, Bijenicka 54, HR-10000 Zagreb, Croatia.
2. FREE RADICAL BIOLOGY AND MEDICINE 33-09/2002: The effect of MZM on TAS of Healthy individuals and patients with malignant diseases. Ivkovic S, Zabcic D. Megamin International
3. Biochem Biophys Res Commun. 2011 Jul 8;410(3):478-83. Epub 2011 Jun 7. Zeolites are effective ROS-scavengers in vitro. Pellegrino P, Mallet B, Delliaux S, Jammes Y, Guieu R, Schäf O. Laboratoire de Biochimie, Hôpital Timone, 27 Bd Jean Moulin, F-13385 Marseille Cedex 05, France.
4. Life Sci. 2013 May 20;92(17-19):903-10. Epub 2013 Apr 3. Dietary zeolite supplementation reduces oxidative damage and plaque generation in the brain of an Alzheimer’s disease mouse model. Montinaro M1, Uberti D, Maccarinelli G, Bonini SA, Ferrari-Toninelli G, Memo M.

Improve Nutrient Digestibility

Zeosen® interacts in galt which induces:

• Increased macrophage and DC response
• CD4 CD8 proliferation
• Improvement of gut cellular barrier

1. J Cancer Res Clin Oncol. 2002 Jan;128(1):37-44. Epub 2001 Nov 10. Immunostimulatory effect of natural clinoptilolite as a possible mechanism of its antimetastatic ability. Pavelic K, Katic M, Sverko V, Marotti T, Bosnjak B, Balog T, Stojkovic R, Radacic M, Colic M, Poljak-Blazi M. Rudjer Boskovic Institute, Division of Molecular Medicine, Bijenicka 54, HR-10000 Zagreb, Croatia.
2. Adv Ther. 2004 Mar-Apr;21(2):135-47. Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system. Ivkovic S, Deutsch U, Silberbach A, Walraph E, Mannel M.Megamin GmbH, Berlin, Germany